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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10065 | 2',3'-cGAMP | 2'-3'-cyclic GMP-AMP | STING , cGAS |
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3'-cGAMP binds to STING to form a dimer, inducing the produc... | |||
T38328 | CU-32 | ||
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS ... | |||
T36985 | Cyclic di-UMP (sodium salt) | ||
Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or ds... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10065L | 2',3'-cGAMP sodium | 2'-3'-cyclic GMP-AMP sodium | STING , cGAS |
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium), a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate imm... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01166 | CGAS Protein, Human, Recombinant (His) | Human | E. coli |
CGAS Protein, Human, Recombinant (His) is expressed in E. coli. |